Intrauterine growth retardation – a developmental model of type 2 diabetes
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چکیده
منابع مشابه
Intrauterine growth retardation leads to the development of type 2 diabetes in the rat.
Intrauterine growth retardation has been linked to the development of type 2 diabetes in later life. The mechanisms underlying this phenomenon are unknown. We have developed a model of uteroplacental insufficiency, a common cause of intrauterine growth retardation, in the rat. Bilateral uterine artery ligation was performed on day 19 of gestation (term is 22 days) in the pregnant rat; sham-oper...
متن کاملEpigenetic Changes Predisposing to Type 2 Diabetes in Intrauterine Growth Retardation
Epidemiologic studies have demonstrated an association between intrauterine growth retardation and a greater risk of chronic disease, including coronary heart disease, hypertension, stroke, and type 2 diabetes in adulthood. An adverse intrauterine environment may affect both growth and development of the organism, permanently programming endocrine and metabolic functions. One of the mechanisms ...
متن کاملIntrauterine growth retardation.
The recognition that some low birthweight babies (<2500 g) were the victims of intrauterine growth retardation rather than premature birth was a milestone in perinatal medicine.'3 Up to 10% of all liveborn babies and at least 30% of those of low birth weight suffer from intrauterine growth retardation; their perinatal mortality is four to 10 times higher than that of normally grown babies-both ...
متن کاملIntrauterine Growth Retardation
Intrauterine growth retardation (IUGR) refers to fetal growth that has been constrained in utero. It results in newborns that have not attained their full growth potential and are already malnourished at birth. Fetuses that suffer from growth retardation have higher perinatal morbidity and mortality and are more likely to experience poor cognitive development and neurologic impairment during ch...
متن کاملHepatic insulin resistance precedes the development of diabetes in a model of intrauterine growth retardation.
Intrauterine growth retardation (IUGR) has been linked to the development of type 2 diabetes in adulthood. We developed an IUGR model in rats whereby at age 3-6 months the animals develop a diabetes that is associated with insulin resistance. Hyperinsulinemic-euglycemic clamp studies were performed at age 8 weeks, before the onset of obesity and diabetes. Basal hepatic glucose production (HGP) ...
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ژورنال
عنوان ژورنال: Drug Discovery Today: Disease Models
سال: 2013
ISSN: 1740-6757
DOI: 10.1016/j.ddmod.2013.01.003